Abstract: Large Research Infrastructure(LRI) is the pioneer capital for the development of a science and technology power and an innovation-oriented country. Being strategic, intensive invested and public focused, LRI is the foundation of the national innovation ecosystem. For a long time, there is a lack of targeted LRI evaluation methods to guide the improvement of investment efficiency. This paper aims at value orientation of LRI’s transformative development in the new period, in reference to the international methods, makes clear of LRI evaluation principle, builds "function, goal, input, activity, output, effect” evaluation logic, and forms the “frame-criterion-standard-actor” evaluation framework, and puts forward the LRI evaluation index system. At last, the practical application of LRI evaluation framework and index is discussed.