Abstract: Disciplinary convergence is a new trend of large-scale interdisciplinary integration, which will have a profound impact on knowledge production and scientific research organization. In this paper, we take Wyss Institute for Biologically Inspired Engineering at Harvard University and Tsinghua University's School of Life Sciences as examples. Using bibliometrics and network analysis to analyze the knowledge structure and process of disciplinary convergence. The results show that: Based on the commonness and complementarity of the underlying knowledge units, discipline convergence presents the characteristics of discipline-group knowledge structure of life science, material science and Engineering Science; disciplinary convergence is a gradual process from adjacent knowledge domain to remote knowledge fields, and the degree of collaborative progress among discipline groups is gradually enhanced. These will provide support and enlightenment for us to better understand the law of interdisciplinary integration, coordinate planning of discipline development, and focus on basic research.