Abstract: As the trade friction between China and the United States continues, the cultural differences between countries have become an important factor affecting international trade. This article measures the cultural heterogeneity with the new cultural distance. Under the conditions of controlling the institutional distance, geographical distance and differences in digital technology applications, the 2008-2017 integrated panel data is used to empirically test the mechanism and effect of cultural heterogeneity on manufacturing export. The results show that: (1) cultural heterogeneity helps to increase the export scale of manufacturing; (2) the impact of cultural heterogeneity on exports has two kinds of "multiple demand positive effect" and "transaction cost reverse effect" Mechanism; (3) The application of digital technology weakens the positive effect of diversified demand and the reverse effect of transaction costs, and overall reduces the positive effect on manufacturing exports. Therefore, policy should pay attention to the complementarity between technology and culture, and promote the development of international trade through the two-wheel drive of culture and technology.