Abstract: With the transformation of main social contradiction, theimbalance of innovation-driven force of Chinese regional manufacturing industry is increasingly prominent. How to narrow the regional gap of innovation-driven development, build an innovation-driven community and promote innovation-driven regional coordinated development has become an important topic in theory and reality. Based on the analysis of the connotation of innovation-driven force of manufacturing industry, this paper constructs the evaluation index system of innovation-driven force of manufacturing industry by taking technological innovation and system innovation as the core. Then, the innovation-driven force of manufacturing industry are comprehensively analyzed in the whole country, east, central and west sub-regions, as well as sub-provinces by using the grey correlation projection comprehensive evaluation model based on the entropy method. The results show that: From 2006 to 2017, the innovation-driven force in Chinese manufacturing industry is on the rise in general. However there are obvious differences in the innovation-driven force of manufacturing industry among and within different regions. For this reason, the Gini coefficient is used to analyze the differences of innovation-driven force ofChinese regional manufacturing industry. The result shows that the difference ofinnovation-driven force of Chinese regional manufacturing industrypresents a trend of gradually widening. That is to say, it is embodied in an obvious "Matthew effect". This paper provides some policy implications for China to better implement the innovation-driven development strategy of manufacturing industry and promote the regional coordinated development of innovation-driven of manufacturing industry, so as to promote the construction of a strong manufacturing country and science and technology powers.