Abstract: Under the background of "decoupling theory", the relationship between independence and openness of enterprise’ independent innovation needs to be explained theoretically. Most of the traditional innovation studies are based on the diffusion model, which holds that independence is the transcendental inherent attribute of technology, so there is no need to explain the relationship between independence and openness. However, from the perspective of actor network theory, independent innovation is based on the translation model, and the attribute of technology is not transcendental, but is co-defined by the actors involved. The translation model attempts to restore the emerging innovation, rather than trying to explain the factors that affect innovation, because these factors are uncertain until the innovation is completed. The research on Huawei 5G technology innovation based on the translation model shows that the independence of technology innovation can be divided into two aspects. On the one hand, as the center of the accumulative cycle, the innovation subject should rely on the accumulative cycle to bring back the knowledge and redefine the knowledge. On the other hand, the innovation subject should make the relevant technology become the international standard of the industry and define the “obligatory passage point”, and this is accomplished through open negotiations with other actors in the process of commercialization of technology. From the perspective of traditional innovation theory, knowledge is ready-made, so traditional innovation theory only pays attention to the study of Huawei's global R&D system. While from the perspective of actor-network theory, if we do not understand what it means to acquire knowledge, then the so-called “knowledge” can’t be defined. Huawei not only uses its global R&D system to pool scattered innovation resources into itself, but more importantly, in the process, it continues to redefine knowledge through the accumulative cycle. Finally, knowledge is moved into Huawei, resulting in new technologies and patents, breaking the "open paradox" that traditional innovation theory cannot overcome. In addition, Huawei has also incorporated these technologies and patents into international technical standards through negotiations with other actors, promoting them to become a “obligatory passage point” for the industry. In this process, technology is not immutable, but constantly changing with the negotiation of actors. Only when the negotiation is completed, technological innovation can be completed. The reason why the redefinition of knowledge and the definition of "obligatory passage point" can become an important embodiment of Huawei's independent innovation is due to the power given by the actor network. The power of the actor network comes from the heterogeneous actors. To maintain the power of the actor network needs to be open to other actors and constantly translate more actors. So, the stronger the power of the actor network, the stronger the independence of technology innovation. In this sense, technology innovation is not only a process of technological research in the laboratory, but also a process of interaction between technology and society, and a process of open negotiations with other actors. Therefore, the independence and openness of enterprise’ independent innovation not only do not contradict each other, but also its independence is emerged from this kind of openness.