Abstract: The United States is the main promoter of the reform of international intellectual property rules. By tying up intellectual property protection and foreign trade, the United States promotes higher standards of intellectual property protection and law enforcement around the world. After years of practice, the United States has flexibly used the (early) multilateral mechanism of trips and the (recent) selective multilateral, small multilateral and bilateral free trade agreements to improve the standards of intellectual property protection, forming a global intellectual property protection network closely coordinated by domestic legislative, administrative and judicial departments.With the help of Special Section 301 and its annual reports, the United States frequently outputs pressure of intellectual property to foreign countries by design, to supervise trade partners’ enforcement of intellectual property and force them to establish US-led rules of intellectual property protection. Based on 33 Special 301 reports issued by Office of the United States Trade Representative from 1989 to 2022, this paper analyzes the changes in the pressure of the United States on Intellectual property in China and predicts the future development trend. The conclusion shows that the adjustment of China's intellectual property system is accompanied by the external pressure of the United States and presents a cyclical feature. The pressure of intellectual property on China continues to be distributed in international rules and domestic legal system, national intellectual property protection and law enforcement system, counterfeiting and piracy and global law enforcement cooperation, pan national security and high-tech industry competition. While continuing to pay attention to the new development of traditional key issues, the focus is on the evolution of global competition involving national security and industry. In the future, China and the United States will continue to engage in fierce games on key intellectual property issues such as national security, high-tech industries, digital economy, and market access for information and communication technology products. China should take the initiative to study and evaluate the reform trend of the world intellectual property system, strengthen the reform pilot mechanism and national innovation measures of intellectual property protection, make policies according to the key categories of predictable pressures, formulate national intellectual property foreign policies scientifically, effectively resolve the external pressures of intellectual property, and actively participate in the global governance of intellectual property.