Abstract: Open science is innovators open knowledge disclosure behavior, it can promote openness and sharing of knowledge, and improve social welfare of innovation. Open science universal exist in academic and industrial sectors, it has ‘science-business’ dual value.This study provides a new explanation for scientists’s motivations, and builds a theoretical framework from‘career-property-status-economic’ motivations perspective. Using survey data from 883 academic and industrial scientists, we examine the rationality of theoretical framework, and find the differences between academic and industrial scientists in open science motivation. Our findings have important implications for innovation research as well as for policy makers and managers.