Abstract: Innovation district was first defined by Bruce J. Katz at the Brookings Institution，within which research area is still in the ascendant. By using anchoring plus innovation districts as the research objects, and based on the data sources of the ACS 2010-2014 and US census 2000, this paper investigates the interaction relationships among Entrepreneur/talEnt-innovation District-University by constructing the EDiU model, which is the extension of the triple helix model from spatial projection and reconstruction; also choose single case study of Kendall Square and compared case study for the seven anchoring plus innovation districts. The results illustrate net inflow of talents is the core driver of innovation district development within which young talents especially university graduates play the vital role in such development. Moreover, diversification of real estate helps to meet the needs of different groups of people in the innovation districts and the industrial diversification contributes to the construction of regional innovation eco-system. These findings can be interpreted as highly attentions should be paid to the process of innovation agglomeration mode by focusing on two aspects, which are the effective implementation of the young talents management and innovation management on grid or district, and the boom the other asset markets via the boom of the human capital market.