Abstract: Computational Social Science is an emerging interdisciplinary research field, and its connotation, characteristics and prospect have not been comprehended adequately by the circle of social science. In addition, there is a considerable divarication in these issues as well. Therefore, we interviewed several influential American computational social scientists on some basic questions about Computational Social Science, including its definition, relationship with traditional social science, reliability of the knowledge produced, main challenges and prospect, etc. Through these interviews, we hope to deepen domestic academia’s understanding of Computational Social Science, and thus promote related research.