Abstract: How team mindset affect team scientific creativity is not only an emerging topic in the field of scientific creativity under the background of innovation-driven development strategy, but also an important issue faced by innovation education in colleges and universities under the background of emerging engineering construction. Referring to the theories of creativity component and social cognition, we take the science and technology innovation team of science and engineering college students as research samples and construct a moderated chain mediation effect model. The experimental study shows that team mindset has a significant positive effect on team scientific creativity. The questionnaire survey shows that team creative efficacy and team cognitive flexibility not only play a role of single mediation but also chain mediation in the relationship between team mindset and team scientific creativity; open communication moderates the relationships between team mindset and team creative efficacy, team cognitive flexibility and team scientific creativity. These findings have important theoretical implications and practical significance for team scientific and technological innovation.