Abstract: The commercialization of technology from universities and public research institutions is gaining more attention. In order to transform their basic scientific research more effectively, science-based firms are born, which are closely linked to basic scientific research and seek to obtain financial returns from technical transformation. This paper selects the successful case from university in China, and studies the commercialization of the achievements from the perspective of science-based firms. The research of this paper shows: (1) For the basic scientific research, the establishment of "science-based firms" is an effective way to achieve the commercialization of technical; (2) the deep participation of scientists in commercialization is an effective way to achieve tacit knowledge transfer; (3) the establishment of long-term cooperation and feedback mechanism between science-based firms and universities or research institutions is conducive to cultivate the ability of knowledge absorption and form the continuous innovation ability of the firms; (4) The multiple support from governments could reduce the risk and provide a good environment for innovation.