Abstract: Based on the sample of new type of research institutes in Yangtze River Delta and structural equation modeling method, this paper empirically examines the influence factors and the action mechanism of innovation performance of new type of research institutes. The results show that network relations and the abilities of resource integration of new type of research institutes is positively related to innovation performance. We also find that the market mechanism has a positive impact on innovation performance and it mediates the relationship between network relations and innovation performance and the relationship between the abilities of resource integration and innovation performance. Besides, this paper also suggests that the innovation environment plays a positive moderating role on the relationships between the network relations and innovation performance of the new type of research institutes, and the relationships between market mechanism and innovation performance.