Abstract: the dialectical unity of scientific and technological self-reliance and open innovation. The new development pattern of "double cycle" provides new ideas and strategic carriers for the coordinated development of the two, which is of great significance for building a world scientific and technological power. The thought of system theory is the theoretical basis of the organic coordination between scientific and technological self-reliance and open innovation under the pattern of "double circulation". The three subsystems of "science technology market" are interconnected, effectively linked and synergetic, which is the theoretical framework of self-reliance and open synergy under the new pattern of "double cycle". The coordination paths of the two include: first, strengthen international cooperation in basic research and promote the diversified open mode of combining large and small cycles under the "external cycle"; Second, efficient internal cooperation: bridge the "fracture" of the domestic industry university research association's co innovation chain and improve the self-reliance of science and technology under the "internal cycle"; Third, the coordination of internal and external circulation: promoting the outside from the inside and promoting the inside from the outside, and the two wheel drive of scientific and technological self-reliance and open innovation.