Abstract: Why can outstanding entrepreneurs demonstrate excellent business management and leadership? This paper proposes the concept of entrepreneurial vitality as an analytical framework. We conduct in-depth interview with 30 entrepreneurs who appear in the featured report of China Entrepreneur magazine from 2017 to 2020. This study finds that the vitality quality of Chinese entrepreneurs includes four dimensions, namely energy, vigilance, tenacity, and peace. Among them, energy and vigilance belong to the vitality characteristics proposed by the Western scholars, while tenacity and peace are the unique vitality characteristics in the context of Chinese traditional culture. In this sense, the vitality of Chinese entrepreneurs is also inward-looking, including the elements of indulgence, restraint, and inner peace.