Abstract: Ambidextrous innovation plays an important role in the process of high-quality sustainable development of firms. Resource-based theory suggests that unique and valuable knowledge is the key to innovation. Proactive boundary-spanning search, as an important way to acquire external knowledge, can facilitate ambidextrous innovation. Therefore, it is worth exploring how proactive boundary-spanning search affects ambidextrous innovation. Moreover, in the new normal of VUCA and the era of digital intelligence, firms not only need to have organizational resilience to cope with external emergencies and unexpected events, but also need to have digital capability to orchestrate and utilize knowledge. Thus, it is necessary to uncover the relationship between proactive boundary-spanning search and ambidextrous innovation by considering organizational resilience and digital capability. Drawing on resource-based theory, dynamic capabilities theory and information processing theory, this study explores the impact of proactive boundary-spanning search on ambidextrous innovation and organizational resilience, and examines the moderating role of digital capability. Based on the data of 268 knowledge-intensive firms, the empirical results indicate that proactive boundary-spanning search has an inverted U-shaped relationship with exploratory innovation and exploitative innovation, and it also has an inverted U-shaped relationship with organizational external and internal resilience. The results also find that organizational external resilience partially mediates the relationship between proactive boundary-spanning search and exploratory innovation, while organizational internal resilience partially mediates the relationship between proactive boundary-spanning search and exploitative innovation. Moreover, digital capability moderates and flattens the inverted U-shaped relationship between proactive boundary-spanning search and organizational external and internal resilience, respectively. This study has four theoretical contributions. First, the research uncovers the nonlinear impact of proactive boundary-spanning search on exploratory innovation and exploitative innovation. Based on resource-based theory, the results reveal that proactive boundary-spanning search is an important antecedent of ambidextrous innovation and it plays double-edged sword effect on ambidextrous innovation. This deeply reveals the internal driving mechanism of proactive boundary-spanning search on ambidextrous innovation. Second, the research clarifies the nonlinear effects of proactive boundary-spanning search on organizational external resilience and internal resilience. Drawing on dynamic capabilities theory, the study reveals the important role of proactive boundary-spanning search in organizational external and internal resilience, and enriches the research on the antecedents of organizational resilience. Third, the study elucidates the mediating role of organizational resilience among proactive boundary-spanning search and exploratory and exploitative innovations under the new normal of VUCA. The results clarify the effect of proactive boundary-spanning search on exploratory innovation and exploitative innovation via different organizational resilience, and provide new insights for the relationship between proactive boundary-spanning search and ambidextrous innovation. Fourth, the study finds the moderating effect of digital capability on the inverted U-shaped relationship among proactive boundary-spanning search and organizational external and internal resilience, which uncovers the mechanism of proactive boundary-spanning search on ambidextrous innovation by considering organizational resilience and digital capability under the new normal of VUCA and the era of digital intelligence, and provides theoretical guidance for Chinese firms to carry out ambidextrous innovation.