Abstract: Ethical governance of science and technology is an important measure to promote the healthy and sustainable development of science and technology. However, there are different understandings on the interpretation of the connotation, extension and boundary about ethical governance of science and technology. In this paper, ethical governance of science and technology is supposed to include three levels: first is the governance of issues that violate ethics that occur at the frontier of science and technology, which considers ethical issues of science and technology as governance object; second is the ethical governance of science and technology, where ethics acts as a governance methodology and important tool, emphasizing the normative and restrictive of ethics; the last one is the ethical governance of scientific and technological activities, that is, a good governance emphasizes that the process and purpose must be responsible and consistent with human well-being, and should be morally justifiable.