Abstract: In the era of globalization, the landscape of innovation has transcended national boundaries. Against the backdrop of the contemporary scientific and technological milieu, China is actively crafting a novel developmental paradigm. This paradigm pivots around the domestic cycle as its nucleus while concurrently harnessing the synergistic forces of both domestic and international cycles to propel advancement. In the unfolding narrative of the "double-cycle new development pattern," the confluence of Indigenous innovation networks and Global innovation networks becomes an inexorable phenomenon. Extant scholarly endeavors have primarily scrutinized discrete domains, encompassing Corporate innovation networks, Regional innovation networks, and Global innovation networks, each in isolation. These inquiries have dissected their genesis, evolutionary dynamics, interlinkages, and reciprocal influences on innovation outcomes. However, a noticeable gap persists in our understanding of the interplay between Indigenous innovation networks, their intricate subsystems, and the expansive tapestry of Global innovation networks. This research lacuna warrants meticulous exploration to enrich our comprehension of the intricate coupling mechanisms engendered by these networks. The synergistic development of indigenous innovation and global innovation is a cutting-edge topic in the field of regional innovation. Revealing the coupled and synergistic status between China's Indigenous Innovation Networks (IINs) and Global Innovation Networks (GINs) is of significant guidance in establishing a new development pattern that promotes the domestic and international dual circulation and implementing the "going global and bringing in" strategy. Therefore, this paper traces the development trajectory of IINs and GINs, constructs an indicator system to characterize both networks, utilizes the entropy weight method to calculate the comprehensive development index of the two networks, and then measures the coupling and development levels between the national and four major regional innovation networks and GINs. Finally, the Dagum Gini coefficient and kernel density estimation method are used to examine regional differences, their sources, and distribution dynamics. The research findings indicate that the coupling and synergistic nature of China's IINs-GINs is on the rise, but the overall level is not high and is still in the early stage of coordinated development. Within the IINs system, the coupling level between the innovation environment and GINs is the highest, representing China's advantage in innovation development. The differences in the coupling and synergistic development of China's IINs-GINs are widening, with regional disparities being the main source. The results of this study provide an important reference for comprehensively and objectively understanding the current status of the coupling and coordination between regional and provincial innovation and global innovation development in China, as well as for formulating rational innovation-driven policies to achieve high-quality economic development.