Abstract: Technology lock-in blocking the emergence and survival of disruptive innovation. Our paper divided the factors that lead to technology lock-in into two aspects: technical entanglement and interest correlation. The survival analysis method is used to study the survival state of 8106 technical standards from Searle Center Database. The results show that: (1) The more complex the technology is and the more industries, the easier it is to form technology lock-in; (2) the mechanism for maintaining the vested interests of enterprise is strongest, while the influence of the technical alliance and government intervention is the second; (3) Technology lock-in that lead by government is especially significant after the technology has survived for more than 20 years. In order to prevent technology lock-in, it is recommended to limit SEP owners to excessively capture technical monopoly interests, and encourage bottom-up multi-level technology alliances to participate in the formulation of technical standards. At the same time, the government should not participate too much in the technical standards setting process.